Exosomes play a significant role in the body’s physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, preservation and formulation are a major challenge in clinical and commercial success.
Exosomes are a promising cell-free therapy, but they cannot be stored for a long time. Therefore, it is necessary to have a reliable exosomes preservation technology to protect their biological activities and make them convenient for transportation and clinical application. Currently, the applied protection techniques mainly include freezing, freeze-drying and spray-drying. All these methods are not successful to prevent the aggregation, loss of composition, biological potency and structural integrity of exosomes.
Various studies have reported optimal and reproducible storage conditions of exosomes isolated from culture media and body fluids such at RT to -80oC. However, compared with freshly extracted exosomes, storage at -80 °C for 4 days will change the morphology of exosomes, and the biological activity of exosomes will be reduced during storage at −80 °C for 28 days.
Lihan Biologics is coming up with Exo-preserve a novel technology which overcomes the limitations of current storage/transportation methods and helps the researchers to store and transport the exosomes at room temperature for minimum 30 days.