Exosomes, a group of vesicles originating from the multivesicular bodies, are released into the extracellular space when these bodies fuse with the plasma membrane. Exosomes play important roles in cell-to-cell communication and display multiple functions such as exerting positive effects on regeneration in many tissues. Exosomes contain endogenous proteins and nucleic acids, delivery of these molecules to exosome-recipient cells causes biological effects. Exosomes derived from various types of stem cells and immune cells have therapeutic potential and are biocompatible and efficient agents against various degenerative diseases and able to modify the function of the receptor cells and tissues. Exosomes are involved in the pathogenesis of diseases such as cancer and neurodegenerative diseases like Parkinson’s disease and Alzheimer’s disease as well as the process of the immune response and harbor a more promising future.
The therapeutic use of exosomes is expanding rapidly but standardization of experimental application and technical variation is a limiting step in exosome isolation, characterization, and finding accurate dosing regimens. Fundamental improvements in exosome study design are required to improve the interpretation of efficacy and to ensure reproducibility and comparability across preclinical studies.
We provide commercial exosome extraction and yield high numbers of exosomes, after purification. There are other open areas such as the process where the exosomes choose respective cargo to transport, and the way the cells take up the exosomes. Clinical trials using exosomes show that naive exosomes are often insufficient to produce strong responses in vivo thus we offer a solution to improve the efficacy of exosomes by engineering them for different treatment approaches. These strategies include the addition of extracellular stimuli, surface modifications, and loading therapeutic agents into exosomes by using our proprietary technologies for the treatment of various tumors and degenerative diseases.